Nga korero whanui
Ko te Retinol-binding protein 4 (RBP4) te kaikawe motuhake mo te retinol (e mohiotia ana ko te huaora A), a ko te kawenga mo te hurihanga o te retinol kore e u, me te kore e rewa i roto i te wairewa wai ki roto ki te matatini me te wairewa i roto i te plasma na roto i o raatau taunekeneke.I te mea he mema o te lipocalin superfamily, ko te RBP4 kei roto i te hanganga β-barrel me te kohanga kua tino tautuhia ka hunahia mai i te ate, a, ka tukuna e ia te retinol mai i nga toa ate ki nga kopa peripheral.I roto i te plasma, ko te RBP4-retinol complex e taunekeneke ana me te transthyretin (TTR), he mea nui tenei here mo te aukati i te RBP4 excretion i roto i te whatukuhu glomeruli.Ko te RBP4 i puta mai i te puna ectopic he pai te tuku retinol ki nga kanohi, a, ko tana ngoikoretanga ka pa te nuinga o te tirohanga o te po.I tata nei, ko te RBP4 hei adipokine, ka kitea e whakaatuhia ana i roto i te kiko adipose me te hono ki te nui, te aukati insulin (IR) me te mate huka momo 2 (T2DM).
Tohutohu Takirua | CLIA (Hopu-Hoki): 9D11-8 ~ 3D4-1 3C8-1 ~ 3D4-1 |
Maamaa | >95% i whakatauhia e SDS-PAGE. |
Whakatairanga Buffer | PBS, pH7.4. |
Rokiroki | Whakaorangia i raro i nga tikanga parakore i te -20 ℃ ki te -80 ℃ ina whiwhi. Ka tūtohu kia tohatohahia te pūmua ki nga rahinga iti mo te rokiroki pai. |
Ingoa Hua | ngeru.Kao | TT Clone |
RBP4 | AB0032-1 | 9D11-8 |
AB0032-2 | 3C8-1 | |
AB0032-3 | 3D4-1 | |
AB0032-4 | 1C6-1 |
Tuhipoka: Ka taea e te Bioantibody te whakarite i nga rahinga mo o hiahia.
1.Aiwei YB, Vijayalakshmi V, Bodles AM, et al.Retinol binding protein 4 expression in humans: relationship to insulin resistance, mumura, and response to pioglitazone.[J].J Clin Endocrinol Metab(7):2590-2597.
2.Haider DG, Karin S, Gerhard P, et al.Ko te serum retinol-binding protein 4 ka whakahekehia i muri i te ngaronga o te taumaha i roto i nga kaupapa mate momo.[J].Journal of Clinical Endocrinology & Metabolism(3):1168-71.